Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumoniae.

Tigecycline is considered one of the last-resort antimicrobials for carbapenem-resistant K. pneumoniae. Plasmid-mediated tigecycline resistance remains largely unclear. Here, by utilizing whole genome sequencing, we report a plasmid-mediated tigecycline resistance mechanism, a 6, 489bp Resistance-nodulation-division family (RND) efflux pump (tmexCD1-toprJ1 pump), that confers transferable tigecycline resistance in K pneumoniae isolated from patients and chickens.

In addition, we identified high prevalence of the plasmids co-harboring both tmexCD1-toprJ1 pump and mcr (tmexCD1-mcr co-harboring plasmid) from human in our nationwide collection. Even worse, the tmexCD1-toprJ1 and mcr co-harboring plasmid was also co-existed with bla_NDM-harboring IncX3 plasmid in the same host, resulting in pandrug resistance. Phylogenetic analysis suggested that the plasmid-borne tmexCD1-toprJ1 originated from the chromosome of Aeromonas spp. 

Cystatin D Recombinant Protein
96-209	ProSci	0.05 mg	EUR 569
Description: Cystatin-5 (CST5) is also known as Cystatin-D, is a secreted thermostable protein, which belongs to the cystatin family. CST5 is a cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. CST5 / cystatin-D may play a protective role against proteinases present in the oral cavity.

Bradford Assay Kit, 1,000 tests
209	AthenaES	Kit	EUR 184

PTC-209
HY-15888	MedChemExpress	10mg	EUR 211

WYC-209
HY-124136	MedChemExpress	10mM/1mL	EUR 618

PTC-209
B3179-10	ApexBio	10 mg	EUR 235
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209
B3179-2	ApexBio	2 mg	EUR 152
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209
B3179-5	ApexBio	5 mg	EUR 166
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209
B3179-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 374
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209
B3179-50	ApexBio	50 mg	EUR 595
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209
B1055-25	Biovision		EUR 588

PTC-209
B1055-5	Biovision		EUR 196

Mouse Sickle tail protein (SKT) ELISA Kit
abx389166-96tests	Abbexa	96 tests	EUR 911

Mouse Sickle tail protein, Skt ELISA KIT
ELI-29595m	Lifescience Market	96 Tests	EUR 865

Human Sickle tail protein homolog, SKT ELISA KIT
ELI-18163h	Lifescience Market	96 Tests	EUR 824

hCRP FRET 96
CH1021-96	Mediomics	1 Kit	EUR 455

hCRP TRF 96
CHTR1021-96	Mediomics	1 Kit	EUR 482

hInsulin FRET 96
IH1017-96	Mediomics	1 Kit	EUR 455

hInsulin TRF 96
IHTR1017-96	Mediomics	1 Kit	EUR 482

hAlbumin FRET 96
AH1005-96	Mediomics	1 Kit	EUR 455

hAlbumin TRF 96
AHTR1005-96	Mediomics	1 Kit	EUR 482

mIgG TRF 96
MIGTR1020-96	Mediomics	1 Kit	EUR 482

rIgG FRET 96
RI1024-96	Mediomics	1 Kit	EUR 455

PTC-209 (hydrobromide)
HY-15888A	MedChemExpress	10mg	EUR 211

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit
EF014796	Lifescience Market	96 Tests	EUR 689

EIF4E (Ab-209) Antibody
CSB-PA190338-	Cusabio		EUR 335
Description: A polyclonal antibody against EIF4E (Ab-209). Recognizes EIF4E (Ab-209) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

EIF4E (Ab-209) Antibody
CSB-PA190338-100ul	Cusabio	100ul	EUR 316
Description: A polyclonal antibody against EIF4E (Ab-209). Recognizes EIF4E (Ab-209) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

eIF4E (Ab-209) Antibody
21226-100ul	SAB	100ul	EUR 252

eIF4E (Ab-209) Antibody
21226-50ul	SAB	50ul	EUR 187

anti-eIF4E (Ab-209)
LF-PA20134	Abfrontier	100 ul	EUR 334
Description: Rabbit polyclonal to eIF4E

HSP70 ELISA Kit
SKT-105-96	Cusabio	1 plate of 96 wells	EUR 581
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit
SKT-106-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit
SKT-107-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)
SKT-108-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit
SKT-109-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit
SKT-110-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit
SKT-111-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit
SKT-113-96	Stressmarq	1 plate of 96 wells	EUR 633
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit
SKT-123-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)
SKT-124-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit
SKT-126-96	Stressmarq	1 plate of 96 wells	EUR 460
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit
SKT-137-96	Stressmarq	1 plate of 96 wells	EUR 632
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit
SKT-140-96	Stressmarq	1 plate of 96 wells	EUR 566
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Cortisol EIA Kit
SKT-201-96	Stressmarq	1 plate of 96 wells	EUR 329
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Glutathione Detection Kit
SKT-202-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Glutathione S-Transferase Activity Kit
SKT-203-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish

Glutathione Reductase Activity Kit
SKT-204-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human

Corticosterone EIA Kit
SKT-205-96	Stressmarq	1 plate of 96 wells	EUR 355
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species

Cortisone CLIA Kit
SKT-206-96	Stressmarq	1 plate of 96 wells	EUR 467
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species

Prostaglandin E2 EIA Kit
SKT-207-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP CLIA Kit (High-Sensitivity)
SKT-208-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic GMP CLIA Kit (High-Sensitivity)
SKT-210-96	Stressmarq	1 plate of 96 wells	EUR 520
Description: Direct CLIA kit used to measure cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Cyclic GMP EIA Kit
SKT-211-96	Stressmarq	1 plate of 96 wells	EUR 474
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Nitric Oxide Detection Kit
SKT-212-96	Stressmarq	2 plates of 96 wells	EUR 342
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Retinol Binding Protein Urinary EIA Kit
SKT-218-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used to measure RBP levels in urine samples in Urine samples from Human, Rat, Dog, Monkey

Cystatin C EIA Kit
SKT-219-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Sandwich EIA kit used to measure cystatin C levels in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media samples from Human

Tissue Culture Plate, 96 Well
TCP20-96	Bio Basic	1 UNIT	EUR 53.48

Aligned Nanofibers 96 Well Plate
3D00012-96	Neuromics	700 nm-PCLs	EUR 110

Bridge-It cAMP-PDE 96
PD1016-96	Mediomics	1 Kit	EUR 455

Mouse Lymphocyte Antigen 96 ELISA kit
E03L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Lymphocyte Antigen 96 ELISA kit
E02L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Lymphocyte Antigen 96 ELISA kit
E01L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Lymphocyte Antigen 96 ELISA kit
E07L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Lymphocyte Antigen 96 ELISA kit
E06L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Lymphocyte Antigen 96 ELISA kit
E04L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Lymphocyte Antigen 96 ELISA kit
E08L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Lymphocyte Antigen 96 ELISA kit
E09L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Native Bacillus sp. Leucine dehydrogenase
DIA-209	Creative Enzymes	5KU	EUR 2765

anti-Rpn12 (yeast) antibody, rabbit purified antibody
62-209	Sceti	20uL	EUR 375
Description: The anti-Rpn12 (yeast) antibody, rabbit purified antibody is available in Europe and for worldwide shipping via Gentaur.

A549/GFP Cell Line
AKR-209	Cell Biolabs	1 vial	EUR 572
Description: A549/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

BSA (Bovine Serum Albumin; 10 mg/ml, MBG) in NEB-buffer
209-005	GeneOn	4 x 1,5 ml	EUR 52

BSA (Bovine Serum Albumin; 10 mg/ml, MBG) in NEB-buffer
209-005W	GeneOn	4 x 1,5 ml	EUR 52

SARS-CoV-2 (COVID-19) Spike S1 Recombinant Protein
10-209	ProSci	0.1 mg	EUR 542.75
Description: The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensinconverting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

GUCY2C / Guanylyl cyclase C Recombinant Protein
11-209	ProSci	0.1 mg	EUR 595.25
Description: GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

SARS-CoV-2 (COVID-19) NSP13 Recombinant Protein
20-209	ProSci	0.1 mg	EUR 605.75
Description: SARS-CoV-2 (COVID-19) NSP13 Recombinant Protein

IL-38 Recombinant Protein
90-209	ProSci	50 ug	EUR 826.25
Description: IL-38 (IL-1F10) belongs to the IL-1 family. IL-38 is expressed in the fetal skin, spleen and tonsil, generally in the basal epithelia of skin and in proliferating B cells of the tonsil. IL-38 binds soluble IL-1 receptor type 1 and may be implicated in the regulation of adapted and innate immune responses.

GGPPSase Recombinant Protein
91-209	ProSci	0.05 mg	EUR 710.75
Description: Geranylgeranyl pyrophosphate synthase (GGPS1) is a member of the FPP/GGPP synthase family. GGPS1 is highly expressed in testis, heart and skeletal muscle. GGPS1 is localized in the cytoplasm and has geranylgeranyl diphosphate (GGPP) synthase activity. It catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Other transcriptional splice variants have been found.

Sterol O-acyltransferase 2 Recombinant Protein
92-209	ProSci	0.05 mg	EUR 710.75
Description: ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus.

Spleen Lysate
21-209	ProSci	0.1 mg	EUR 285.5
Description: Monkey (Cynomolgus) spleen tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Cynomolgus) spleen tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the spleen tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The spleen tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Oncostatin M (209 a.a.), human
RC214-19T	Bio Basic	2ug	EUR 104.38

Polyclonal HDAC4 Antibody (aa194-209)
APR12340G	Leading Biology	0.05mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HDAC4 (aa194-209). This antibody is tested and proven to work in the following applications:

Anti-eIF4E (Ab-209) Antibody
A00135	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal eIF4E (Ab-209) Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

G209-2M; gp100 (209-217)
5-01171	CHI Scientific	4 x 5mg	Ask for price

Oncostatin-M (209 a.a.) Protein
20-abx262209	Abbexa	EUR 328.00 EUR 5826.00 EUR 230.00	10 ug 1 mg 2 µg

Transmembrane Protein 209 (TMEM209) Antibody
20-abx301967	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

eIF4E (Ab-209) Conjugated Antibody
C21226	SAB	100ul	EUR 397

96 WELL CLEAR PCR MICROPLATE
PCR-96-C	CORNING	10/pk	EUR 145
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

Guinea pig Lymphocyte Antigen 96 ELISA kit
E05L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

96 WELL PCR SEGMENTED PLATE
PCR-96-SG-C	CORNING	10/pk	EUR 145
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

96-well Plasmid ezFilter Mini Kit
K1325-96-1	Biovision		EUR 370

96-well Plasmid ezFilter Mini Kit
K1325-96-4	Biovision		EUR 968

Polyclonal CFLAR / FLIP Antibody (aa191-209)
APG02537G	Leading Biology	0.05mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CFLAR / FLIP (aa191-209). This antibody is tested and proven to work in the following applications:

Recombinant Human Oncostatin-M (209 a.a.)
7-01333	CHI Scientific	2µg	Ask for price

Recombinant Human Oncostatin-M (209 a.a.)
7-01334	CHI Scientific	10µg	Ask for price

Recombinant Human Oncostatin-M (209 a.a.)
7-01335	CHI Scientific	1mg	Ask for price

G209-2M; gp100 (209-217) Peptide
20-abx266101	Abbexa	EUR 411.00 EUR 662.00 EUR 314.00	10 mg 25 mg 5 mg

Rat Heat Shock Protein glycoprotein 96 ELISA kit
E02H0282-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Heat Shock Protein glycoprotein 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

through Tn5393-mediating translocation. Both plasmid-harbored tmexCD1-toprJ1 gene and mcr-8 likely originated from animal isolates and then spread to human. Our findings highlight a substantial threat of tmexCD1-toprJ1-mcr8 co-harboring IncFIA/IncFII plasmid to public health due to their mobile resistance to both tigecycline and colistin, emphasizing an urgent need for further global surveillance on this plasmid.