Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumoniae.

Tigecycline is considered one of the last-resort antimicrobials for carbapenem-resistant K. pneumoniae. Plasmid-mediated tigecycline resistance remains largely unclear. Here, by utilizing whole genome sequencing, we report a plasmid-mediated tigecycline resistance mechanism, a 6, 489bp Resistance-nodulation-division family (RND) efflux pump (tmexCD1-toprJ1 pump), that confers transferable tigecycline resistance in K pneumoniae isolated from patients and chickens.

In addition, we identified high prevalence of the plasmids co-harboring both tmexCD1-toprJ1 pump and mcr (tmexCD1-mcr co-harboring plasmid) from human in our nationwide collection. Even worse, the tmexCD1-toprJ1 and mcr co-harboring plasmid was also co-existed with blaNDM-harboring IncX3 plasmid in the same host, resulting in pandrug resistance. Phylogenetic analysis suggested that the plasmid-borne tmexCD1-toprJ1 originated from the chromosome of Aeromonas spp. 

Cystatin D Recombinant Protein

96-209 0.05 mg
EUR 569
Description: Cystatin-5 (CST5) is also known as Cystatin-D, is a secreted thermostable protein, which belongs to the cystatin family. CST5 is a cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. CST5 / cystatin-D may play a protective role against proteinases present in the oral cavity.

Bradford Assay Kit, 1,000 tests

209 Kit
EUR 184

PTC-209

HY-15888 10mg
EUR 211

WYC-209

HY-124136 10mM/1mL
EUR 618

PTC-209

B3179-10 10 mg
EUR 235
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209

B3179-2 2 mg
EUR 152
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209

B3179-5 5 mg
EUR 166
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209

B3179-5.1 10 mM (in 1mL DMSO)
EUR 374
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209

B3179-50 50 mg
EUR 595
Description: PTC-209 is a small-molecule inhibitor of BMI-1 with IC50 value of 0.5 µM [1].PTC-209 is screened out by using gene expression modulation by small molecules (GEMS) technology. It can lower BMI-1 transcript levels.

PTC-209

B1055-25
EUR 588

PTC-209

B1055-5
EUR 196

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 911

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96 Tests
EUR 865

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96 Tests
EUR 824

hCRP FRET 96

CH1021-96 1 Kit
EUR 455

hCRP TRF 96

CHTR1021-96 1 Kit
EUR 482

hInsulin FRET 96

IH1017-96 1 Kit
EUR 455

hInsulin TRF 96

IHTR1017-96 1 Kit
EUR 482

hAlbumin FRET 96

AH1005-96 1 Kit
EUR 455

hAlbumin TRF 96

AHTR1005-96 1 Kit
EUR 482

mIgG TRF 96

MIGTR1020-96 1 Kit
EUR 482

rIgG FRET 96

RI1024-96 1 Kit
EUR 455

PTC-209 (hydrobromide)

HY-15888A 10mg
EUR 211

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit

EF014796 96 Tests
EUR 689

EIF4E (Ab-209) Antibody

CSB-PA190338-
EUR 335
Description: A polyclonal antibody against EIF4E (Ab-209). Recognizes EIF4E (Ab-209) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

EIF4E (Ab-209) Antibody

CSB-PA190338-100ul 100ul
EUR 316
Description: A polyclonal antibody against EIF4E (Ab-209). Recognizes EIF4E (Ab-209) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

eIF4E (Ab-209) Antibody

21226-100ul 100ul
EUR 252

eIF4E (Ab-209) Antibody

21226-50ul 50ul
EUR 187

anti-eIF4E (Ab-209)

LF-PA20134 100 ul
EUR 334
Description: Rabbit polyclonal to eIF4E

HSP70 ELISA Kit

SKT-105-96 1 plate of 96 wells
EUR 581
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit

SKT-106-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit

SKT-107-96 1 plate of 96 wells
EUR 685
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)

SKT-108-96 1 plate of 96 wells
EUR 685
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit

SKT-109-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit

SKT-110-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit

SKT-111-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit

SKT-113-96 1 plate of 96 wells
EUR 633
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit

SKT-123-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)

SKT-124-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit

SKT-126-96 1 plate of 96 wells
EUR 460
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit

SKT-137-96 1 plate of 96 wells
EUR 632
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit

SKT-140-96 1 plate of 96 wells
EUR 566
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Cortisol EIA Kit

SKT-201-96 1 plate of 96 wells
EUR 329
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Glutathione Detection Kit

SKT-202-96 1 plate of 96 wells
EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Glutathione S-Transferase Activity Kit

SKT-203-96 1 plate of 96 wells
EUR 428
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish

Glutathione Reductase Activity Kit

SKT-204-96 1 plate of 96 wells
EUR 428
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human

Corticosterone EIA Kit

SKT-205-96 1 plate of 96 wells
EUR 355
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species

Cortisone CLIA Kit

SKT-206-96 1 plate of 96 wells
EUR 467
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species

Prostaglandin E2 EIA Kit

SKT-207-96 1 plate of 96 wells
EUR 527
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP CLIA Kit (High-Sensitivity)

SKT-208-96 1 plate of 96 wells
EUR 494
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic GMP CLIA Kit (High-Sensitivity)

SKT-210-96 1 plate of 96 wells
EUR 520
Description: Direct CLIA kit used to measure cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Cyclic GMP EIA Kit

SKT-211-96 1 plate of 96 wells
EUR 474
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Nitric Oxide Detection Kit

SKT-212-96 2 plates of 96 wells
EUR 342
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Retinol Binding Protein Urinary EIA Kit

SKT-218-96 1 plate of 96 wells
EUR 527
Description: Sandwich EIA kit used to measure RBP levels in urine samples in Urine samples from Human, Rat, Dog, Monkey

Cystatin C EIA Kit

SKT-219-96 1 plate of 96 wells
EUR 494
Description: Sandwich EIA kit used to measure cystatin C levels in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media samples from Human

Tissue Culture Plate, 96 Well

TCP20-96 1 UNIT
EUR 53.48

Aligned Nanofibers 96 Well Plate

3D00012-96 700 nm-PCLs
EUR 110

Bridge-It cAMP-PDE 96

PD1016-96 1 Kit
EUR 455

Mouse Lymphocyte Antigen 96 ELISA kit

E03L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Lymphocyte Antigen 96 ELISA kit

E02L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Lymphocyte Antigen 96 ELISA kit

E01L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Lymphocyte Antigen 96 ELISA kit

E07L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Lymphocyte Antigen 96 ELISA kit

E06L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Lymphocyte Antigen 96 ELISA kit

E04L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Lymphocyte Antigen 96 ELISA kit

E08L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Lymphocyte Antigen 96 ELISA kit

E09L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Native Bacillus sp. Leucine dehydrogenase

DIA-209 5KU
EUR 2765

anti-Rpn12 (yeast) antibody, rabbit purified antibody

62-209 20uL
EUR 375
Description: The anti-Rpn12 (yeast) antibody, rabbit purified antibody is available in Europe and for worldwide shipping via Gentaur.

A549/GFP Cell Line

AKR-209 1 vial
EUR 572
Description: A549/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.

BSA (Bovine Serum Albumin; 10 mg/ml, MBG) in NEB-buffer

209-005 4 x 1,5 ml
EUR 52

BSA (Bovine Serum Albumin; 10 mg/ml, MBG) in NEB-buffer

209-005W 4 x 1,5 ml
EUR 52

SARS-CoV-2 (COVID-19) Spike S1 Recombinant Protein

10-209 0.1 mg
EUR 542.75
Description: The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensinconverting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

GUCY2C / Guanylyl cyclase C Recombinant Protein

11-209 0.1 mg
EUR 595.25
Description: GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

SARS-CoV-2 (COVID-19) NSP13 Recombinant Protein

20-209 0.1 mg
EUR 605.75
Description: SARS-CoV-2 (COVID-19) NSP13 Recombinant Protein

IL-38 Recombinant Protein

90-209 50 ug
EUR 826.25
Description: IL-38 (IL-1F10) belongs to the IL-1 family. IL-38 is expressed in the fetal skin, spleen and tonsil, generally in the basal epithelia of skin and in proliferating B cells of the tonsil. IL-38 binds soluble IL-1 receptor type 1 and may be implicated in the regulation of adapted and innate immune responses.

GGPPSase Recombinant Protein

91-209 0.05 mg
EUR 710.75
Description: Geranylgeranyl pyrophosphate synthase (GGPS1) is a member of the FPP/GGPP synthase family. GGPS1 is highly expressed in testis, heart and skeletal muscle. GGPS1 is localized in the cytoplasm and has geranylgeranyl diphosphate (GGPP) synthase activity. It catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Other transcriptional splice variants have been found.

Sterol O-acyltransferase 2 Recombinant Protein

92-209 0.05 mg
EUR 710.75
Description: ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus.

Spleen Lysate

21-209 0.1 mg
EUR 285.5
Description: Monkey (Cynomolgus) spleen tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Cynomolgus) spleen tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the spleen tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The spleen tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Oncostatin M (209 a.a.), human

RC214-19T 2ug
EUR 104.38

Polyclonal HDAC4 Antibody (aa194-209)

APR12340G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HDAC4 (aa194-209). This antibody is tested and proven to work in the following applications:

Anti-eIF4E (Ab-209) Antibody

A00135 100ul
EUR 397
Description: Rabbit Polyclonal eIF4E (Ab-209) Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

G209-2M; gp100 (209-217)

5-01171 4 x 5mg Ask for price

Oncostatin-M (209 a.a.) Protein

20-abx262209
  • EUR 328.00
  • EUR 5826.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

Transmembrane Protein 209 (TMEM209) Antibody

20-abx301967
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

eIF4E (Ab-209) Conjugated Antibody

C21226 100ul
EUR 397

96 WELL CLEAR PCR MICROPLATE

PCR-96-C 10/pk
EUR 145
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

Guinea pig Lymphocyte Antigen 96 ELISA kit

E05L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

96 WELL PCR SEGMENTED PLATE

PCR-96-SG-C 10/pk
EUR 145
Description: PCR Plates & Tubes; A354 PCR Plate-Axygen

96-well Plasmid ezFilter Mini Kit

K1325-96-1
EUR 370

96-well Plasmid ezFilter Mini Kit

K1325-96-4
EUR 968

Polyclonal CFLAR / FLIP Antibody (aa191-209)

APG02537G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CFLAR / FLIP (aa191-209). This antibody is tested and proven to work in the following applications:

Recombinant Human Oncostatin-M (209 a.a.)

7-01333 2µg Ask for price

Recombinant Human Oncostatin-M (209 a.a.)

7-01334 10µg Ask for price

Recombinant Human Oncostatin-M (209 a.a.)

7-01335 1mg Ask for price

G209-2M; gp100 (209-217) Peptide

20-abx266101
  • EUR 411.00
  • EUR 662.00
  • EUR 314.00
  • 10 mg
  • 25 mg
  • 5 mg

Rat Heat Shock Protein glycoprotein 96 ELISA kit

E02H0282-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Heat Shock Protein glycoprotein 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

through Tn5393-mediating translocation. Both plasmid-harbored tmexCD1-toprJ1 gene and mcr-8 likely originated from animal isolates and then spread to human. Our findings highlight a substantial threat of tmexCD1-toprJ1-mcr8 co-harboring IncFIA/IncFII plasmid to public health due to their mobile resistance to both tigecycline and colistin, emphasizing an urgent need for further global surveillance on this plasmid.